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Patients who have multiple active injury sites, chronic inflammatory conditions that affect more than one tissue type, or a history of repeated injuries that have created a background state of persistent low-grade inflammation are exactly the patients for whom TB-500’s systemic distribution mechanism is most clinically relevant

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On the other hand, the lack of a significant anxiolytic effect with GABA treatment raises questions about its bioavailability or receptor interactions in the specific context of the EPM test, possibly due to differences in the route of administration, dosage, or the animal model’s specific pathology