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There are three classical signal transduction pathways involved in the development of endoplasmic reticulum stress: IRE1, PERK, and ATF6

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Lilly's registered phase 3 trials include studies in obesity or overweight (NCT05929066, 2,335 participants), type 2 diabetes with obesity (NCT05929079), obesity with cardiovascular disease (NCT05882045), knee osteoarthritis (NCT05931367, TRIUMPH-4) and a 10,000-person outcomes trial (NCT06383390, primary completion expected February 2029)