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Supporting these findings, a large cross-sectional analysis from the Lifelines Cohort (11,000 individuals) demonstrated that NS workers exhibited significantly higher counts of leukocytes, monocytes, lymphocytes, and basophil granulocytes compared to non-shift workers, suggesting that frequent or consecutive NSW may acutely stimulate immune cell mobilization and contribute to systemic inflammation 112

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– Delta Sleep‑Inducing Peptide (DSIP) is the primary peptide that induces sleep by directly deepening delta‑wave activity